Chukwueze has scored three goals and recorded three assists in 26 league appearances for the Yellow Submarine this season.
The 22-year-old is expected to be named in the starting line-up for the game by Villarreal’s manager Javi Calleja.
Calleja’s men occupy ninth position in the table and a win will boost their hopes of playing in Europe next season.
At the Estadio Municipal de Burtaque, Super Eagles duo, Kenneth Omeruo and Chidozie Awaziem and their Leganes team-mates will continue their push against relegation against Real Valladolid.
Leganes sit in 19th position in the the LaLiga table with 23 points from 27 games.
Omeruo has featured in 19 league games for Leganes and scored once, while Awaziem, who is loan at the club from Portuguese giants FC Porto has made 18 appearances.
By Adeboye Amosu
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