Club Brugge will host the first leg encounter at their home ground, Jan Breydelstadion.
Dennis has featured in 10 games in Europe for Club Brugge this season and scored three times.
Okereke, 22, has played eight games for the club but is yet open to his account for the season.
Brugge head into the game in boisterous mood after edging out Waasland Beveren 2-1 in their league game last weekend.
Manchester United recorded a 2-1 away win against Chelsea in a Premier League name on Monday.
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