Coronavirus: What to know about Chloroquine

March 21, 2020
229 Views

Chloroquine is a medication used to prevent and to treat malaria in areas where malaria is known to be sensitive to its effects.

Occasionally, it is used for amebiasis that is occurring outside the intestines, rheumatoid arthritis, and lupus erythematosus.

Now it is being used experimentally to treat COVID-19 as of 2020.

In late January 2020 during the 2019–20 coronavirus outbreak, Chinese medical researchers stated that exploratory research into chloroquine and two other medications, remdesivir and lopinavir/ritonavir, seemed to have fairly good inhibitory effects on the SARS-CoV-2 virus, which is the virus that causes COVID-19

Then, on 19 February 2020, preliminary results found that chloroquine may be effective and safe in treating COVID-19 associated pneumonia.

The Guangdong Provincial Department of Science and Technology and the Guangdong Provincial Health and Health Commission issued a report stating that chloroquine phosphate improves the success rate of treatment and recommended it for people diagnosed with mild, moderate and severe cases of novel coronavirus pneumonia.

Chloroquine has a very high volume of distribution, as it diffuses into the body’s adipose tissue.

Chloroquine is also a lysosomotropic agent, meaning it accumulates preferentially in the lysosomes of cells in the body.

The PKA for the Quinoline Nitrogen of Chloroquine is 8.5, meaning it is about 10% deprotonated at Physiological PH as calculated by the Henderson-Hasselbalch Equation.

The lysosomotropic character of chloroquine is believed to account for much of its antimalarial activity; the drug concentrates in the acidic food vacuole of the parasite and interferes with essential processes.

Its lysosomotropic properties further allow for its use for in vitro experiments pertaining to intracellular lipid related diseases.

It is sunned up, therefore, that with this development, it appears there is hope of recovery from the dreaded virus that has ravaged the globe, claiming dozens of lives.

You may be interested

BREAKING: AGN reacts to death rumours of Zack Orji
News
News

BREAKING: AGN reacts to death rumours of Zack Orji

Webby - March 26, 2024

The Actors Guild of Nigeria, AGN, has debunked the report that Nollywood actor, Zack Orji is dead. The news emerged…

BREAKING: Chinese who killed lover in Kano sentenced to death
News
4 views
News
4 views

BREAKING: Chinese who killed lover in Kano sentenced to death

Webby - March 26, 2024

Justice Sanusi Ado Ma’aji of Kano state high court sitting at Miller road, Bompai, has found Quandong Geng, a Chinese…

Mamu Rejects Terrorism Financing Allegation, Demands Retraction
News
News

Mamu Rejects Terrorism Financing Allegation, Demands Retraction

Webby - March 26, 2024

Tukur Mamu Tukur Mamu, the publisher of Kaduna-based Desert Herald Newspaper, is demanding a retraction from the Attorney General of…

Leave a Comment

Your email address will not be published.