Stanley Dimgba missed the chance to put Enyimba ahead from the spot in the 26th minute.
Sadiq Abubakar put the visitors ahead on the half hour mark following a brilliant solo effort.
Chukwuemeka Obioma, on loan from Enyimba added a second for Heartland late in the first half.
Enyimba fought hard to get back into the game after the break but Heartland goalkeeper Ikechukwu Ezenwa produced a number of impressive saves to deny the home team.
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The Flying Antelopes raced into a two-goal lead early in the game courtesy of fine strikes from Kelvin Itoya and Kenechukwu Agu.
Charles Atsemene reduced the deficit for the hosts four minutes before the break.
Rangers finished the game with 10 men after Agu was sent off for a second booking after an elbow offence on Abu Azeez.
In Akure, Plateau United went down to a 2-1 defeat against Sunshine Stars.
Timileyin Ogunniyi fired Sunshine Stars ahead in the 11th minute after he was teed up by Anthony Omaka.
Fuad Ekelojuoti doubled the Owena Waves lead in the 33rd minute.
Uche Onwuasonya reduced the deficit three minutes before the half hour mark after he was set up Michael Ibeh.
Rivers United moved to second position in the table following a 2-1 win against leaders Lobi Stars at the Aper Aku Stadium in Makurdi.
Nelson Esor nodded home Konan Ruffin’s cross in the second minute, while John Lazarus slidded home Omotayo Adebogun’s clever pass for the equaliser in the 19th minute.
Malachi Ohawume netted the winning goal for Rivers United 15 minutes from time.
At the Godswill Akpabio Stadium, Uyo, Kwara United ended Akwa United’s six-game unbeaten streak by edging out the hosts 2-0.
Alao Danbani scored both goals for the Kwara United.
Seun Adelani Yusuf put Pillars ahead in the 34th minute, while Tasiu Lawal equalised for the hosts 10 minutes later.
MFM came back from a goal down to beat Jigawa Golden Stars 2-1 at the Agege Stadium.
Joshua Akpuje conceded an own goal on the hour mark but he later scored twice in the 41st and 69th minutes respectively to hand the Olukoya Boys all three points in the game.
Lukman Hello and Yakub Hammed were on target for Abia Warriors in the game, while Jimoh Gbadamosi scored the visitors only goal from the spot.
Wolves 1-2 Rangers
Abia Warriors 2-1 FC Ifeanyiubah
Enyimba 0-2 Heartland
Katsina Utd 1-1 Kano Pillars
Akwa Utd 0-2 Kwara Utd
Sunshine Stars 2-1 Plateau Utd
MFM 2-1 Jigawa GS
Rivers Utd 2-1 Lobi
Adamawa Utd 0-0 Wikki
By Adeboye Amosu
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