The Nigerian forward scored twice in the second half – in the 65th and 78th minutes of the encounter.
The goals ended Onyekuru’s six-game goal drought in the Turkish Super Lig.
Sofiane Feghouli, Badou Ndiaye and Mbaye Diagne were also on target for Galatasaray.
The win moved Galatasaray back to second place in the Turkish Super Lig table with 49 points from 25 games.
Istanbul Basaksehir currently leads the log with 57 points from 25 games.
Onyekuru who has been called up for Nigeria’s 2019 Africa Cup Of Nations qualifier against Seychelles and for an international friendly against Egypt in Asaba Delta State, has made seven appearances for the three-time AFCON champions.
By Johnny Edward.
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