Remdesivir drug not good for COVID-19: WHO

November 20, 2020
3 Views

<!– Remdesivir: WHO says the drug made by Gliead Science not OK for covid-19 –>

Remdesivir: WHO says the drug made by Gliead Science not OK for covid-19

By Agency Reporter

The World Health Organisation in a stunning announcement Friday said Gilead’s drug remdesivir is no longer recommended for patients hospitalised with COVID-19, regardless of how ill they are.

According to a WHO panel, there is no evidence it improves survival or reduces the need for ventilation.

The Ebola drug was one of the drugs used to treat U.S. President Donald Trump’s coronavirus infection, and had been shown in previous studies to have cut time to recovery.

It is authorised or approved for use as a COVID-19 treatment in more than 50 countries

But a WHO advisory said the drug is no more efficacious, following but a large WHO-led trial known as the Solidarity Trial.

The trial showed last month that it had little or no effect on 28-day mortality or length of hospital stays for COVID-19 patients.

“The … panel found a lack of evidence that remdesivir improved outcomes that matter to patients such as reduced mortality, need for mechanical ventilation, time to clinical improvement, and others,” the guideline said.

The advice is another setback for the drug, which grabbed worldwide attention as a potentially effective treatment for COVID-19 in the summer after early trials showed some promise.

At the end of October, Gilead cut its 2020 revenue forecast, citing lower-than-expected demand and difficulty in predicting sales of remdesivir.

The antiviral is one of only two medicines currently authorised to treat COVID-19 patients across the world,

Gilead has questioned the Solidarity Trial’s results.

“Veklury is recognised as a standard of care for the treatment of hospitalised patients with COVID-19 in guidelines from numerous credible national organisations,” Gilead said in a statement, referring to the drug’s brand name.

“We are disappointed the WHO guidelines appear to ignore this evidence at a time when cases are dramatically increasing around the world and doctors are relying on Veklury as the first and only approved antiviral treatment for patients with COVID-19.”

The WHO’s Guideline Development Group (GDG) panel said its recommendation was based on an evidence review that included data from four international randomised trials involving more than 7,000 patients hospitalised with COVID-19.

After reviewing the evidence, the panel said, it concluded that remdesivir, which has to be given intravenously and is therefore costly and complex to administer, has no meaningful effect on death rates or other important outcomes for patients.

“Especially given the costs and resource implications associated with remdesivir …the panel felt the responsibility should be on demonstrating evidence of efficacy, which is not established by the currently available data,” it added.

The latest WHO advice comes after one of the world’s top bodies representing intensive care doctors said the antiviral should not be used for COVID-19 patients in critical care wards.

The WHO’s recommendation, which is not binding, is part of its so-called “living guidelines” project, designed to offer guidance for doctors to help them make clinical decisions about patients in fast-moving situations such as the COVID-19 pandemic.

The guidelines can be updated and reviewed as new evidence and information emerges.

The panel said, however, that it supported continued enrolment into clinical trials evaluating remdesivir in patients with COVID-19, which it said should “provide higher certainty of evidence for specific groups of patients”.

The recommendation may raise further questions about whether the European Union will need the 500,000 courses of the antiviral worth 1 billion euros it ordered last month.

You may be interested

Rihanna is reportedly dating rapper A$AP Rocky
News
1 views
News
1 views

Rihanna is reportedly dating rapper A$AP Rocky

Webby - December 2, 2020

<!-- Rihanna and A$AP Rocky --> Rihanna and A$AP Rocky By Taiwo Okanlawon Barbadian singer and businesswoman, Robyn Rihanna Fenty…

COVID-19 kills 3 in Nigeria, 281 new cases recorded
News
5 views
News
5 views

COVID-19 kills 3 in Nigeria, 281 new cases recorded

Webby - December 2, 2020

<!-- Lagos leads new COVID-19 -->Lagos leads new COVID-19 Three persons in Nigeria died from COVID-19 related causes in the…

Boko Haram Claims Responsibility For Zabarmari Massacre
News
4 views
News
4 views

Boko Haram Claims Responsibility For Zabarmari Massacre

Webby - December 2, 2020

Boko Haram Insurgents Boko Haram Insurgents have revealed that they are responsible for the killings of over 43 farmers in…

Leave a Comment

Your email address will not be published.