Success has struggled to stay on his feet since his arrival at the London club from Spanish club Granada in 2015.
The 24-year-old has managed four league appearances for the Hornets this season.
The Nigerian was linked with a move away from the club in January but opted to remain at the club and fight for his place.
“Isaac Success has ruptured his Achilles. Deulofeu won’t be available this season, he’s got a serious knee injury with his cruciate. Janmaat won’t be available either,” Pearson said at Thursday’s news conference.
“But everybody else more or less is available. We’ve tried to prepare the players at a pace which really does reflect very much where they are themselves.”
By Adeboye Amosu
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